Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p120 | (1) | ICCBH2013

Osteoblasts communicate with their neighbouring cells via extracellular vesicles

Morhayim Jess , Demmers Jeroen , de Jong Ton , Braakman Eric , de Peppel Jeroen van , Cornelissen Jan , van Leeuwen Hans

Objectives: Strong coordination between osteoblasts and bone marrow cells is fundamental for the regulation of healthy bone turnover and other (patho)physiological processes. Extracellular vesicles (EVs) mediate communication between cells via horizontal transfer of proteins and nucleic acids. Osteoblasts secrete EVs in the form of matrix vesicles involved in bone mineralization, however, information about a role in intercellular communication is still lacking. In this study, ...